The risk of having a serious adverse reaction to the COVID-19 vaccine is very low—far lower than the risk of contracting COVID-19. 

Severe adverse reactions after vaccination are extremely rare, but can cause long-term health issues. Rare adverse events – such as anaphylaxis and other allergic reactions, blood-clotting syndromes, heart inflammation, autoimmune diseases impacting the nervous system, and death – have been identified and investigated through the Vaccine Adverse Event Reporting System (VAERS)

Common reactions to COVID-19 vaccination include mild side effects, such as limb soreness, fatigue, low-grade fever, headaches, and chills. These reactions typically resolve within a few days.

Updated December 14, 2023