Yes, COVID-19 vaccines have a very strong safety record. The COVID-19 vaccines have been tested and monitored for safety more than any previous vaccine in U.S. history. All COVID-19 vaccines have been rigorously tested and reviewed for human safety through a three-phase clinical trial process. 

More than 150,000 people participated in U.S. vaccine clinical trials, and almost 700 million vaccine doses have been safely administered in the U.S., with rare instances of adverse reactions. To ensure the continued safety of COVID-19 vaccines, data from clinical trials is collected and monitored for two years after each vaccine is first administered. Additional monitoring is in place for adverse event reporting through the Vaccine Adverse Event Reporting System (VAERS). Based on these thorough processes, public health officials make evidence-based recommendations to keep the public safe and healthy.

Updated December 14, 2023