Communicating About Placebo-Controlled Trials and Other Kinds of Comparison Studies


Information about placebo-controlled trials is appearing in the news and social media more frequently. Use these talking points to answer your community members’ questions about placebo-controlled trials, when they are typically used, and when a different type of comparison study may be used. 

Key Talking Points

  • One way that scientists test the safety and efficacy of a new vaccine is by comparing it to an immunologically inactive substance: a substance that does not include any active elements of a vaccine. An immunologically inactive substance is also called a placebo. In a comparison study, also known as a placebo-controlled trial, some participants receive the vaccine being tested. The other participants receive a placebo, like a saltwater solution, that does not actually impact the body’s response to an infection. Comparing the outcomes of these two participant groups helps scientists determine whether receiving the vaccine is better than not receiving the vaccine. 
  • Other kinds of comparison studies don’t use an immunologically inactive placebo but still provide the evidence needed to determine whether a vaccine is safe and effective.  For example, when testing a vaccine intended to replace an existing, older version of the same vaccine, researchers often conduct an active control (or comparator) trial, in which some participants receive the older version of the vaccine, and the rest of the participants receive the vaccine that is undergoing testing.
  • Ultimately, all vaccines are tested through some kind of comparison trial. Every vaccine is different, and so are the methods used to test each vaccine. Scientists determine which kinds of comparison trials to use based on what is safest, most ethical, and builds on the foundation of what has been learned from previous trials. 
  • Once a new or updated vaccine is being used by the public, the CDC and FDA continue to monitor its safety and effectiveness through various reporting systems, safety assessments, and collaborations with other government agencies and non-government partners.

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